Tubular Tangential Flow Microfiltration System

Tangential Flow Microfiltration is a filtration system with organic tubular ultrafiltration membrane as the filter element. As a form of membrane element, organic tubular membrane is suitable for membrane separation technology such as ultrafiltration and microfiltration. Its advantages are wide flow channel, turbulent flow of feed liquid in the tube, and low requirements for the pretreatment accuracy of feed liquid. Tubular membrane is easy to clean. In addition to chemical reagents, it can also be cleaned by mechanical physical scrubbing. The pressure loss of tubular membrane components is small, so its flow channel is long and the filtration efficiency is high.

Tangential flow microfiltration (TFF) adopted in tangential flow ultrafiltration system is a filtration form in which the flow direction of liquid is tangential (parallel) to the surface of the filter membrane. Compared with the traditional filtration method in which the flow direction is consistent with the filtration direction, the particle accumulation on the surface of the tangential flow filter membrane is less, the filtration speed is stable, and it is suitable for the separation of large volume samples. Among them, molecules larger than the membrane pore size are intercepted and gradually concentrated, and substances smaller than the membrane pore size pass through the membrane and are separated from the macromolecular solution, realizing the separation of macromolecules and small molecules. Therefore, tangential flow ultrafiltration is often used for the concentration, dialysis, buffer exchange, and separation of molecules of different sizes of biological products.

1.Can be used for R&D and production, flexible and versatile

Can stably support all needs from process R&D to pilot scale-up and small-scale commercial production.

2.Easy to linearly convert process parameters

As a production/process exploration equipment with production-level performance, it can provide a stable and reliable development environment when you are developing the process, and consistent process parameters also lay the foundation for subsequent production scale-up.

3.Intelligent automated operation, easy to use and efficient

Flexible and compact plug-and-play hardware design allows the system to quickly switch between various demand management conditions (concentration/diafiltration MF) and R&D/production, greatly improving work efficiency and flexibility, and reducing fixed asset investment.

4.Can be linearly scaled up to industrialization.

Suitable for fermentation tanks and extraction, used for concentration collection/replacement of buffer/washing or clarification filtration after bacterial crushing; can be scaled up to industrial production systems.

1. Use diaphragm pump and high-quality 316L stainless steel pipe components instead of conventional peristaltic pump and silicone hose

2. Use electronic pressure sensor instead of conventional diaphragm pressure gauge

3. Sterile sample cup with stirring (volume can be customized)

4. Temperature sensor

5. Sample cup electronic scale weighing system, secondary peristaltic pump

6. Heat exchange device

7. Circulation flow meter

8. PLC automatic control system and touch screen

Application of tubular Tangential Flow Microfiltration:

Food and beverage

1.Instant tea extraction and deep processing.

2.Fruit and vegetable juice/beverage clarificationand concentration.

3.Wine sterilization and clarification.

4.Dairy sterilization and concentration.

01

Biological medicine

1.Sterilization and clarification of Chinese medicine extracts

2.Removal of pyrogens from Chinese medicine injections

3.Clarification and sterilization of Chinese medicine oral solutions

02

Plant extraction

1.Separation, purification and concentration of natural pigments.

2. Clarification andconcentration of plant extractse.

3.Purification and concentration ofoligosaccharides and polysaccharides.

03

Protein purification

1.Animal protein powder refining and concentration.

2.Peptide/oligopeptide refining and concentration.

3.Animal plasma protein separation and concentration.

4.Milk protein separation and purification

04

1.Cost-efficient: automated manufacturing ensures stable quality and competitive pricing.

2.Flexible customization: capacity, materials, and control logic tailored to your process.

3.One‑stop solution: integration, commissioning, and after‑sales support.

4.Stable scale‑up: consistent parameters from lab to industrial production.

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